Neuroleptic drug-induced dopamine receptor supersensitivity: antagonism by L-prolyl-L-leucyl-glycinamide.
نویسندگان
چکیده
An animal model of tardive dyskinesia was used to evaluate the potential antidyskinetic properties of the neuropeptide L-prolyl-L-leucyl-glycinamide (PLG). In rats, PLG administered concurrently with the neuroleptic drug haloperidol or chlorpromazine antagonized the enhancement of specific [3H]spiroperidol binding in the striatum that is associated with long-term neuroleptic treatment. The results are discussed in relation to a possible functional coupling of the putative PLG receptor with neuroleptic-dopamine receptor complex and clinical implications for tardive dyskinesia.
منابع مشابه
Effect of L-prolyl-L-leucyl-glycinamide (PLG) on neuroleptic-induced catalepsy and dopamine/neuroleptic receptor bindings.
The mechanism of action subserving the potential anti-Parkinsonian properties of L-prolyl-L-leucyl-glycinamide (PLG) was investigated in behavioural and neurochemical models of dopaminergic function in the rat. Acute administration of PLG (20 and 40 mg kg-1 SC) failed to alter appreciably the intensity of the cataleptic response elicited by haloperidol (3 mg kg-1 IP). By contrast, chronic PLG t...
متن کاملAttenuation of Antagonist-induced Impairment of Dopamine Receptors by L-prolyl - L-leucyl-glycinamide
ATTENUATION OF ANTAGONIST-INDUCED IMPAIRMENT IN DOPAMINE RECEPTOR ONTOGENY BY L-PROLYL-L-LEUCYL-GLYCINAMIDE by Mohamad Iqbal Saleh, M.D. It has been shown by others that the prenatal treatment of rats with haloperidol, a dopamine D2 receptor antagonist, leads to a permanent reduction in the number of striatal dopamine D2 receptors in adulthood. Conversely, postnatal treatment of lactating dams ...
متن کاملModulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog.
The present study was undertaken to investigate the role of the hypothalamic tripeptide L-prolyl-L-leucyl-glycinamide (PLG) and its conformationally constrained analog 3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide (PAOPA) in modulating agonist binding to human dopamine (DA) receptor subtypes using human neuroblastoma SH-SY5Y cells stably transfected with respective cDNAs....
متن کاملNeuroleptic-induced supersensitivity psychosis: clinical and pharmacologic characteristics.
Tardive dyskinesia is thought to result from neostriatal dopaminergic receptor supersensitivity induced by chronic treatment with neuroleptics. The authors suggest that dopaminergic supersensitivity also occurs in the mesolimbic region after chronic neuroleptic exposure, resulting in the development of a supersensitivity psychosis. Neuroleptic-induced supersensitivity psychosis is illustrated b...
متن کاملModulation of Agonist Binding to Human Dopamine Receptor Subtypes by L-Prolyl-L-Leucyl-Glycinamide and a Peptidomimetic Analogue
Dept. of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5 (V.V, A.M, W.C, G.P, J.M.C, K.S, S.K, R.KM). Clark Institute of Psychiatry, Toronto, Ontario, Canada (Z.P). Dept. of Medicinal Chemistry, University of Minnesota, Minneapolis, USA (R.L.J). Dept. of Psychiatry, Mount Sinani School of Medicine New York (V.D.N). JPET Fast Forward. Published on...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Science
دوره 214 4526 شماره
صفحات -
تاریخ انتشار 1981